CUDC-101(CUDC101) 乙酰化酶抑制剂 HDAC/EGFR/HER2抑制剂|CAS 1012054-59-9（52715ES）

CUDC-101是一种组蛋白去乙酰化酶的多靶点抑制剂，对HDAC、EGFR、HER2的IC50值分别是4.4 nM、2.4 nM、15.7 nM，且抑制I/Ⅱ型HDACs，但是对Ⅲ型HDACs、Sir-type HDACs没有抑制作用。CUDC-101不仅直接抑制EGFR和HER2信号通路，还间接衰减Akt、HER3和MET信号通路。

参考文献

[1]. Wang J, et al. Potential advantages of CUDC-101, a multitargeted HDAC, EGFR, and HER2 inhibitor, in treating drug resistance and preventing cancer cell migration and invasion. Molecular cancer therapeutics, 2013, 12(6): 925-936.

[2]. Lai C J, et al. CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity. Cancer research, 2010, 70(9): 3647-3656.

冰袋运输。粉末直接保存于-20℃，有效期2年。溶于DMSO。建议分装后-20℃避光保存，避免反复冻融。