IGF-1R选择性抑制剂|苦鬼臼毒素Picropodophyllin(AXL-1717)|CAS 477-47-4（54647ES）

Picropodophyllin，又称苦鬼臼毒素，是可口服的IGF-1R选择性抑制剂，IC₅₀为1 nM，可诱导细胞凋亡，具有抗肿瘤和抗病毒活性。

参考文献

[1] Girnita A, Girnita L, del Prete F, et al. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 2004 Jan 1;64(1):236-42. doi: 10.1158/0008-5472.can-03-2522(IF:8.378).

[2] Menu E, Jernberg-Wiklund H, Stromberg T, et al. Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model. Blood. 2006 Jan 15;107(2):655-60. doi: 10.1182/blood-2005-01-0293(IF:16.562).

[3] Tomizawa M, Shinozaki F, Motoyoshi Y, et al. Picropodophyllin and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells. Oncol Lett. 2014 Nov;8(5):2023-2026. doi: 10.3892/ol.2014.2484(IF:1.871).

-25~-15℃保存，有效期3年。