IBI-334 是一种双特异性 B7-H3 和 EGFR 抗体。IBI-334 具有用于信号阻断的 EGFR 臂，并与具有最佳亲和力和结合域的微调 B7-H3 臂偶联。IBI-334 是无岩藻糖基化的，以增强其抗体介导的细胞毒性 (ADCC) 作用。IBI-334 在许多 EGFR 驱动的实体瘤中具有广泛的应用。

For Powder, reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

本产品仅用作科学研究！

The detected molecular weight of Anti-EGFR & B7-H3 Reference Antibody (Ibi-334) is 145.31 kDa.

Anti-B7-H3 & EGFR Reference Antibody (Ibi-334) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.

The purity of Anti-B7-H3 & EGFR Reference Antibody (Ibi-334) is 99.17%, determined by SEC-HPLC.

Ibi-334 bound to B7-H3 protein, and then rebounded to secondary antibodies (Anti-Human-IgG-Fc-HRP) , and read OD450. As shown in fig, Ibi-334 bound human B7-H3 Protein-His, and the EC50 was 0.033 nM.

Ibi-334 bound to ERBB1/EGFR/HER1 protein, and then rebounded to secondary antibodies(Anti-Human-IgG-Fc-HRP) , and read OD450. As shown in fig, Ibi-334 bound human ERBB1/EGFR/HER1 Protein-His, and the EC50 was 0.029 nM.

Ibi-334 bound to huB7-H3 CHO-K cells, and then rebounded to fluorescent secondary antibodies(Anti-Human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Ibi-334 bound to huB7-H3 CHO-K cells, and the EC50 was 4.066 nM.

Ibi-334 bound to in huEGFR CHO-K cells, and then rebounded to fluorescent secondary antibodies(Anti-Human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Ibi-334 bound to in huEGFR CHO-K cells, and the EC50 was 5.398 nM.

-80°C for 2 years under sterile conditions；-20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles.