This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.

Immunocytochemistry

Immunocytochemistry analysis of ME2 (green) in Jurkat using ME2 antibody,and DAPI(blue).

Western

Western blot analysis of ME2 in mouse intestines, rat spleen lysates using ME2 antibody.

Western

Western blot analysis of ME2 in Ramos lysates using ME2 antibody

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