LW6是HIF-1的抑制剂，IC₅₀值为4.4 μM，缺氧环境下通过降解HIF-1α抑制HIF-1α的积累，但不影响HIF-1α mRNA水平。LW6不影响HIF-1β表达。

参考文献

[1] Naik R, Won M, Ban HS, et al. Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors. J Med Chem. 2014 Nov 26;57(22):9522-38. doi: 10.1021/jm501241g(IF:6.054).

[2] Lee K, Kang JE, Park SK, et al. LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line. Biochem Pharmacol. 2010 Oct 1;80(7):982-9. doi: 10.1016/j.bcp.2010.06.018(IF:4.825).

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