GSK2636771 (GSK-2636771)是可口服的PI3Kβ选择性抑制剂，IC₅₀为5.2 nM，Ki为0.89 nM，对PTEN缺失细胞系敏感，具有选择性抑制活性。

参考文献

[1] Hosford SR, et al. Combined inhibition of both p110α and p110β isoforms of phosphatidylinositol 3-kinase is required for sustained therapeutic effect in PTEN-deficient, ER+ breast cancer. Clin Cancer Res. 2017 Jun 1;23(11):2795-2805.

[2] Weigelt B, et al. PI3K pathway dependencies in endometrioid endometrial cancer cell lines. Clin Cancer Res. 2013 Jul 1;19(13):3533-44.

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议分装后-25~-15℃干燥保存，避免反复冻融。