Monocrotaline (Crotaline)，又称野百合碱、猪屎豆碱、农吉利碱、单响尾蛇毒蛋白或响尾蛇毒蛋白，是从猪屎豆中提取的吡咯烷嗪生物碱，通过对DNA的烃化作用发挥抗癌活性，临床上试用于局部治疗皮肤磷状细胞癌和基底细胞癌。此外，野百合碱还能导致肺动脉高压、右心室肥厚和肺血管系统的病理变化。

参考文献

1. Gomez-Arroyo JG, et al. The monocrotaline model of pulmonary hypertension in perspective. Am J Physiol Lung Cell Mol Physiol. 2012 Feb 15;302(4):L363-9.
2. Kusuma SS, et al. Antineoplastic activity of monocrotaline against hepatocellular carcinoma. Anticancer Agents Med Chem. 2014;14(9):1237-48.
3. Huang WC, et al. Therapeutic Benefits of Induced Pluripotent Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension. PLoS One. 2016 Feb 3;11(2):e0142476.

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