EPZ004777 (EPZ-004777)是一种有效的H3K79甲基转移酶DOT1L选择性抑制剂，IC₅₀为0.4 nM。EPZ004777抑制白血病细胞中H3K79甲基化，并阻碍关键MLL融合靶基因的表达，表现出抗肿瘤活性。

参考文献

1.Daigle SR, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011 Jul 12;20(1):53-65.

2.Chen L, et al. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia. 2013 Apr;27(4):813-22.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。