Oclacitinib maleate (PF-03394197 maleate, PF03394197 maleate)，又称奥拉替尼马来酸盐，是一种新型可口服的JAK抑制剂，IC₅₀分别为10-99 nM，对JAK1最有效，IC₅₀为10 nM。Oclacitinib也能抑制JAK1依赖性细胞因子，IC₅₀为36-249 nM。Oclacitinib maleate可用于各种瘙痒性皮肤病，快速止痒抗炎。

参考文献

1.Gonzales AJ, et al. Oclacitinib (APOQUEL) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacol Ther. 2014 Aug;37(4):317-24.

2.Fukuyama T, et al. Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis. J Pharmacol Exp Ther. 2015 Sep;354(3):394-405.

3.Cosgrove SB, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013 Oct;24(5):479-e114.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。