NSC 42834 (NSC42834, JAK2 Inhibitor V, Z3)，又称JAK2抑制剂V，是JAK2特异性抑制剂，抑制JAK2野生型和突变型JAK2-V617F的自我磷酸化，IC₅₀的范围为10-30 μM，并且在抑制激酶活性的浓度下无细胞毒性。

参考文献

1.Jacqueline Sayyah, et al. Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth. Mol Cancer Ther. 2008 Aug;7(8):2308-18.

2.Jacqueline Sayyah, Peter P. Sayeski. Jak2 inhibitors: Rationale and role as therapeutic agents in hematologic malignancies. Curr Oncol Rep. 2009 Mar;11(2):117-24.

3.Ehab Atallah, Srdan Verstovsek. Prospect of JAK2 inhibitor therapy in myeloproliferative neoplasms. Expert Rev Anticancer Ther. 2009 May;9(5):663-70.

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