AS1517499 (AS-1517499; AS 1517499)是一种高效的STAT6抑制剂（IC₅₀=21 nM），可抑制IL-4诱导的小鼠脾脏T细胞向Th2分化，也可通过抑制气管平滑肌中RhoA的上调，减缓抗原诱导的气管平滑肌高反应性。 

参考文献

[1]. Xuechao Jiang, Bingbing Zha, Xiaoming Liu, et al. STAT6 deficiency ameliorates Graves’ disease severity by suppressing thyroid epithelial cell hyperplasia. 2016, 7(12): e2506-e2506.

[2] Chiba Y, et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am J Respir Cell Mol Biol. 2009 Nov;41(5):516-24.

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