Corynoxeine从钩藤中分离得到的天然产物，一种选择性抑制ERK1/ERK2活性的化合物。Corynoxeine以浓度依赖性方式抑制PDGF-BB诱导的血管平滑肌细胞(VSMCs) DNA合成，抑制ERK1/2活性，抑制细胞增殖，但无任何细胞毒性。Corynoxeine是一种有效的PDGF-BB诱导的VSMCs增殖过程中的ERK1/ERK2抑制剂，对于心血管疾病的预防和治疗有积极作用。

参考文献

[1]. Kim TJ, et al. Corynoxeine isolated from the hook of Uncaria rhynchophylla inhibits rat aortic vascular smooth muscle cell proliferation through the blocking of extracellular signal regulated kinase 1/2 phosphorylation. Biol Pharm Bull. 2008 Nov;31(11):2073-8. 

[2]. Wang W, et al. Effective Separation and Simultaneous Determination of Corynoxeine and Its Metabolites in Rats by High-Performance Liquid Chromatography with Tandem Mass Spectrometry and Application to Pharmacokinetics and In Vivo Distribution in Main Organs. Anal Sci. 2016;32(6):705-7.

[3]. Wang W, et al. Structural elucidation of rat biliary metabolites of corynoxeine and their quantification using LC-MS(n). Biomed Chromatogr. 2014 Sep;28(9):1219-28.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃干燥保存，避免反复冻融。