AX-15836(AX15836) ERK5抑制剂|CAS 2035509-96-5（53122ES）

AX-15836 (AX15836)是有效，选择性的ERK5抑制剂，IC₅₀值为8 nM。 AX-15836是一种选择性的和可逆的ERK5抑制剂，IC50值为8 nM，ERK5的抑制具有抗炎和抗肿瘤作用。在200多种激酶中，AX-15836对ERK5的选择性大于1000倍。

参考文献

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[3]. Tubita A, et al. Playing the Whack-A-Mole Game: ERK5 Activation Emerges Among the Resistance Mechanisms to RAF-MEK1/2-ERK1/2- Targeted Therapy.Front Cell Dev Biol. 2021 Mar 11;9:647311. 

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