Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human Brain Tissue using PPAR delta (4G5) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunohistochemical

Immunohistochemical analysis of paraffin-embedded Human tonsils using PPAR delta (4G5) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.