南美超级胎牛血清999尝鲜特惠
NPB-1575通过IRS2信号通路调节小胶质细胞极化，从而改善缺血性脑损伤。
NPB-1575 improves ischemic brain injury by regulating microglial polarization via IRS2 signaling pathway
Meng-Yao Liu, Xin-Nan Li, Nian-Ying Shang, Li-Wen Zhang, Song-Yang Sui, An-Hua Tao, Jing-Shu Tang, Lei Wu, Jun‑Gui Dai, Ying Peng
Journal：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
IF：1.6
DOI：10.1080/10286020.2026.2726155
PMID：
Published：2026-09-04
research field：生物医学工程药学纳米技术材料科学
Abstract
Modulating microglial polarization is a promising ischemic stroke therapeutic strategy. This study confirms that the novel neuroprotectant NPB-1575 inhibits neuroinflammation and alleviates cerebral ischemic injury. It switches microglial polarization from pro-inflammatory M1 to anti-inflammatory M2 via the IRS2/Nrf2/NF-κB signaling pathway.
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