HmWRKY22-HmABCG1 regulatory module mediates aluminum tolerance through enhanced translocation and antioxidant defense
Ying Hao, Hao Zhou, Shiqin Peng, Qipu Feng, Bo Li, Tailuo Liu, Lifan Xu, Qiyue Liao, Hanif Ullah, Jingruo Chen, Dingyi Zhang, Yuwen Chen, Mao Chen
Journal：ACS Applied Materials & Interfaces
IF：7.8
DOI：10.1021/acsami.6c04164
PMID：42186875
Published：2026-05-26
research field：心血管再生医学生物材料生物医学工程组织工程
Abstract
Ceruletide and L-arginine-induced AP mice were used to evaluate the protective effect of ELE on the pancreas of mice. In the mechanism study, RNA sequencing was used to identify potential signaling pathways in pancreatic tissues from AP mice. Subsequently, pull-down, SPR, and DARTS experiments were performed to identify the binding sites between ELE and IL-17RA. Ixekizumab, a clinically available IL‑17RA monoclonal antibody, was used to confirm IL‑17RA as ELE's key target in the AP mouse model.
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