Valsartan为血管紧张素Ⅱ(AngⅡ)受体拮抗剂，可用于高血压及心力衰竭相关研究。
| 英文别名 (English Synonym) | Valsartan |
| 中文名称 (Chinese Name) | 缬沙坦 |
| 靶点 (Target) | Adenosine Receptor |
| 通路 (Pathway) | GPCR/G protein |
| CAS号 (CAS NO.) | 137862-53-4 |
| 分子式 (Formula) | C24H29N5O3 |
| 分子量 (Molecular Weight) | 435.52 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Shan H, Zhang S, Li X, Yu K, Zhao X, Chen X, Jin B, Bai X. Valsartan ameliorates ageing-induced aorta degeneration via angiotensin II type 1 receptor-mediated ERK activity. J Cell Mol Med. 2014 Jun;18(6):1071-80. doi: 10.1111/jcmm.12251. Epub 2014 Feb 18. PMID: 24548645; PMCID: PMC4508146.[2]Wang Y, Li Y, Shen Q, Li X, Lu J, Li X, Yin D, Peng Y. Valsartan blocked alcohol-induced, Toll-like receptor 2 signaling-mediated inflammation in human vascular endothelial cells. Alcohol Clin Exp Res. 2014 Oct;38(10):2529-40. doi: 10.1111/acer.12532. PMID: 25346502.[3]Sui X, Wei H, Wang D. Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction. J Cell Mol Med. 2015 Aug;19(8):1773-82. doi: 10.1111/jcmm.12551. Epub 2015 Mar 30. PMID: 25823960; PMCID: PMC4549028.[4]Jiang Y, Wang HY, Zheng S, Mu SQ, Ma MN, Xie X, Zhang YY, Zhang CX, Cai JH. Cardioprotective effect of valsartan in mice with short-term high-salt diet by regulating cardiac aquaporin 1 and angiogenic factor expression. Cardiovasc Pathol. 2015 Jul-Aug;24(4):224-9. doi: 10.1016/j.carpath.2014.12.003. Epub 2014 Dec 27. PMID: 25659450.[5]Ping G, Qian W, Song G, Zhaochun S. Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice. Pharmacol Biochem Behav. 2014 Sep;124:5-12. doi: 10.1016/j.pbb.2014.05.006. Epub 2014 May 15. PMID: 24844704.
