甲磺酸培氟沙星是一种广谱抗生素，通过抑制DNA旋转酶和拓扑异构酶I（IC50=45 μg/mL）来阻断DNA复制；它对多种细菌（如大肠杆菌MIC90=0.12 mg/L）和约氏疟原虫具有活性，但需注意其可能加重UVA引起的光毒性和免疫抑制。
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英文别名 (English Synonym) |
Pefloxacin Mesylate |
|
中文名称 (Chinese Name) |
甲磺酸培氟沙星 |
|
靶点 (Target) |
Antibiotic |
|
通路 (Pathway) |
Microbiology/Virology |
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CAS号 (CAS NO.) |
70458-95-6 |
|
分子式 (Formula) |
C18H24FN3O6S |
|
分子量 (Molecular Weight) |
429.46 |
|
纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. doi: 10.1128/mmbr.61.3.377-392.1997. PMID: 9293187; PMCID: PMC232616.[2]Leggett JE, et al. Comparative dose-effect relations at several dosing intervals for beta-lactam, aminoglycoside and quinolone antibiotics against gram-negative bacilli in murine thigh infection and pneumonitis models. Scandinavian Journal of Infectious Diseases, 1991; 74(Suppl): 179-184.
