Calcipotriol 卡泊三醇(维生素D的衍生物)|CAS 112965-21-6（54652ES）

Calcipotriol，又称卡泊三醇，是维生素D的衍生物，通过与细胞表面VD3受体结合抑制皮肤细胞过度增殖诱导其分化，用于治疗牛皮癣。

参考文献

[1] Lovato P, Norsgaard H, Tokura Y, et al. Calcipotriol and betamethasone dipropionate exert additive inhibitory effects on the cytokine expression of inflammatory dendritic cell-Th17 cell axis in psoriasis. J Dermatol Sci. 2016 Mar;81(3):153-64. doi: 10.1016/j.jdermsci.2015.12.009(IF:3.986).

[2] Milczarek M, Chodyński M, Filip-Psurska B, et al. Synthesis and Biological Activity of Diastereomeric and Geometric Analogs of Calcipotriol, PRI-2202 and PRI-2205, Against Human HL-60 Leukemia and MCF-7 Breast Cancer Cells. Cancers (Basel). 2013 Oct 31;5(4):1355-78. doi: 10.3390/cancers5041355.

[3] Cunningham TJ, Tabacchi M, Eliane JP, et al. Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J Clin Invest. 2017 Jan 3;127(1):106-116. doi: 10.1172/JCI89820(IF:12.282).

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