3-Deazaneplanocin A hydrochloride (DZNep hydrochloride, DZNep HCl, NSC 617989 HCl, NSC617989 HCl, NSC 617989 hydrochloride, NSC617989 hydrochloride)，又称3-去氮腺嘌呤A盐酸盐，一种腺苷类似物，具有抗病毒和抗癌活性。DZNep HCl是S-adenosylhomocysteine hydrolase (SAHH)竞争性抑制剂，K_i为50 pM；也是EZH2抑制剂，IC₅₀介于0.08-0.24 μM之间。

参考文献

1. Fiskus W, et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor LBH589 against human AML cells. Blood. 2009 Sep 24;114(13):2733-43.
2. Avan A, et al. Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A with LY 188011 in pancreatic cancer cells. Mol Cancer Ther. 2012 Aug;11(8):1735-46.
3. Kikuchi J, et al. Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells. Lung Cancer. 2012 Nov;78(2):138-43.
4. Tseng CK, et al. Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities. J Med Chem. 1989 Jul;32(7):1442-6.
5. Sun F, et al. Preclinical pharmacokinetic studies of 3-deazaneplanocin A, a potent epigenetic anticancer agent, and its human pharmacokinetic prediction using GastroPlus?. Eur J Pharm Sci. 2015 Sep 18;77:290-302.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。