BOT‑64是一种IκB激酶β(IKKβ)抑制剂，其IC₅₀为1 µM。该化合物能够阻断脂多糖(LPS)诱导的NF‑κB活化以及NF‑κB调控的炎症基因转录。

[1] Kim BH，Roh E，Lee HY，Lee IJ，Ahn B，Jung SH，Lee H，Han SB，Kim Y,Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappaB-regulated gene transcription through inactivating inhibitory kappaB kinase beta,Mol Pharmacol,2008 Apr;73(4):1309-18,doi: 10.1124/mol.107.041251,Epub 2008 Jan 17,PMID: 18202307.