The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

推荐稀释比 WB:1/500-1/1000; ICC/IF:1/100-1/200; FC:1/100-1/200; IP:1; 20-1/50

Western blot analysis of JNK1/2/3 in C6, 3T3 lysates using JNK antibody.

Immunocytochemistry analysis of JNK1/2/3 (green) in Hela using JNK1/2/3 antibody,and DAPI(blue)

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