Drosha was identified as a nuclear RNase III that catalyzes the initial step of microRNA (miRNA) processing. This enzyme processes the long primary transcript pri-miRNAs into stem-looped pre-miRNAs. Interference of Drosha results in the increase of pri-miRNAs and the decrease of pre-miRNAs. Drosha exists in a multiprotein complex called Microprocessor along with other components such as DGCR8. Drosha, along with DGCR8, is necessary for miRNA biogenesis.

推荐稀释比 WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 FC: 1/50-1/100