Cardiomyocyte-derived USP20 mitigates myocardial ischemia/reperfusion injury through deubiquitinating GRP78
Zhenfeng Cheng, Lingfeng Zhong, Miaomiao Ying, Ziyi Huang, Zexin Yang, Wenli Zhang, Zhouqing Huang, Naijin Zhang, Xudong Chen, Xiaoxi Fan, Yucong Zhang, Ruihan Zheng, Keke Ye, Shuang Lin, Weijian Hua
Journal：Theranostics
IF：14.9
DOI：10.7150/thno.132067
PMID：42370198
Published：2026-06-17
research field：分子生物学细胞生物学心脏病学
Abstract
Myocardial ischemia/reperfusion (I/R) injury remains a major clinical challenge characterized by cardiomyocyte loss and adverse remodeling after reperfusion. Ubiquitin-Specific Peptidase 20 (USP20), a deubiquitinase involved in cellular stress responses, has not been fully characterized in the ischemic heart. This study aimed to investigate the function and mechanism of cardiomyocyte-derived USP20 in myocardial I/R injury.
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