Echinocystic acid prevents obesity and fatty liver via interacting with FABP1
Lianggui Xiao, Mingming Li, Yang Xiao, Lin Yu, Yu Li, Zhiwang Zhang, Guo Zhang, Yixing Li, Lei Zhou, Yunxiao Liang
Journal：PHYTOTHERAPY RESEARCH
IF：7.2
DOI：10.1002/ptr.7839
PMID：37092723
Published：2023-04-24
research field：分子生物学药理学细胞生物学营养学遗传学与基因组学生物化学
Abstract
Long-term high-fat diet (HFD) will lead to obesity and their complications. Echinocystic acid (EA), a triterpene, shows anti-inflammatory and antioxidant effects. We predict that EA supplementation can prevent obesity, diabetes, and nonalcoholic steatohepatitis. To test our hypothesis, we investigated the effects of EA supplementation on mice with HFD-induced obesity in vivo and in vitro by adding EA to the diet of mice and the medium of HepG2 cells, the protein target of EA was analyzed by molecular docking. The results showed that EA ameliorated obesity and inhibited blood triglyceride and liver triglyceride concentrations than those in the HFD groups. The data on molecular docking indicated that FABP1 was a potential target of EA. Further experimental results confirmed that EA affected the triglyceride level by regulating the function of FABP1. This study may provide a new potential inhibitor for FABP1 and a new strategy for the treatment of obesity.
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