Organic Dye Nanoparticles with a Special D−π–A Structure for Photoacoustic Imaging and Photothermal Therapy
Weilong Feng, Wanyi Zhao, Zhuo Chen, Chuangli Zhang, Jiechao Ge, Xiuli Zheng, Haohui Ren, Shuhui Bo
Journal：ACS Applied Bio Materials
IF：0
DOI：10.1021/acsabm.0c00504
PMID：
Published：2020-08-03
research field：肿瘤学治疗诊断学生物医学工程呼吸生物学纳米技术材料科学
Abstract
FTC dye with a D-π-A structure showed outstanding stability, high extinction coefficient, and good photothermal performance. Thus, nanoparticles based on FTC dye were first fabricated by a nanoprecipitation method for photothermal therapy (PTT) which was guided by photoacoustic imaging (PAI). The prepared FTC NPs showed a photothermal conversion efficiency of ∼52.71%, good photoacoustic performance, and excellent stability in in vitro experiments. Moreover, FTC NPs showed good performance in tumor ablation under a 635 nm laser irradiation and low cytotoxicity to the mice model without laser treatment. Histopathological analysis further confirmed that FTC NPs did not harm the major organs of mice. Given the abovementioned features, FTC NPs have great potential to be effective phototheranostic materials for PAI and PTT.
本文使用的Yeasen产品
