热收缩电纺纤维胶带用于非侵入性恢复松弛软组织结构和功能的研究

Abstract

Non‐invasive recovery of loose soft tissue caused by trauma, organ expansion, or compression has not been solved properly. Herein, a new approach of heat‐shrinkable electrospun fibrous tape (HS‐EFT) is constructed via electrospinning in which the contraction of the poly(lactic‐co‐glycolic acid) HS‐EFT causes the relaxed fascia to pull back at body temperature while the mechanical force of retraction is transformed into an external signal that regulates the behavior of fibroblasts. As it contracts more than 40% within five days, the fast proliferation of fibroblasts on the contracted fibrous membrane is observed followed by the formation of more stress fibers, consequently promoting the nuclear transfer of mechanical stimulation‐sensitive co‐transcriptional molecule, yes‐associated protein (YAP), and eventually making new extracellular matrix (ECM) deposition, as well as tissue strengthen. Moreover, in the process of fascia defect repairing in rabbits, the loose tissue is gathered by fibrous tape which ends in a reduced wound area as well as tissue repairing. Therefore, the HS‐EFT provides great inspiration for the reconstruction of relaxed soft tissue both structurally and functionally in a non‐invasive way.