Zebularine (4-Deoxyuridine, NSC309132, NSC-309132)，又称泽布拉林或2-嘧啶酮-B-核甙，一种胞苷类似物，最初是用作是胞苷脱氨酶抑制剂，K_i为2 μM。Zebularine是一种有效的DNA甲基转移酶抑制剂，但不是选择性抑制剂，与DNA甲基转移酶形成共价复合物。Zebularine可使超甲基化沉默的基因去甲基化和活化。

参考文献

1.Champion C, et al. Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine. PLoS One. 2010 Aug 24;5(8):e12388.

2.Cheng JC, et al. Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst. 2003 Mar 5;95(5):399-409.

3.Billam M, et al. Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells. Breast Cancer Res Treat. 2010 Apr;120(3):581-92.

4.Lemaire M, et al. Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine. Cancer Chemother Pharmacol. 2009 Feb;63(3):411-6.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。