Barasertib-HQPA (AZD2811)是一种高选择性极光激酶B抑制剂,可诱导癌细胞生长阻滞与凋亡。
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英文别名 (English Synonym) |
Barasertib (AZD1152-HQPA) |
|
中文名称 (Chinese Name) |
巴拉塞替-HQPA |
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靶点 (Target) |
Aurora Kinase |
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通路 (Pathway) |
Epigenetics |
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CAS号 (CAS NO.) |
722544-51-6 |
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分子式 (Formula) |
C26H30FN7O3 |
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分子量 (Molecular Weight) |
507.56 |
|
纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Yang J, Ikezoe T, Nishioka C, Tasaka T, Taniguchi A, Kuwayama Y, Komatsu N, Bandobashi K, Togitani K, Koeffler HP, Taguchi H, Yokoyama A. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood. 2007 Sep 15,110(6):2034-40. doi: 10.1182/blood-2007-02-073700. Epub 2007 May 10. PMID: 17495131.[2]Wilkinson RW, Odedra R, Heaton SP, Wedge SR, Keen NJ, Crafter C, Foster JR, Brady MC, Bigley A, Brown E, Byth KF, Barrass NC, Mundt KE, Foote KM, Heron NM, Jung FH, Mortlock AA, Boyle FT, Green S. AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res. 2007 Jun 15,13(12):3682-8. doi: 10.1158/1078-0432.CCR-06-2979. PMID: 17575233.
