Tanshinone IIA是丹参根中的主要活性二萜醌成分，可通过靶向血管内皮生长因子及其受体2的蛋白激酶结构域抑制血管生成；该化合物还是天然的单酰基甘油脂肪酶抑制剂，用于心血管疾病与炎症性疾病的治疗。
| 英文别名 (English Synonym) | Tanshinone IIA |
| 中文名称 (Chinese Name) | 丹参酮IIA |
| 靶点 (Target) | IκB/IKK |
| 通路 (Pathway) | Immunology/Inflammation |
| CAS号 (CAS NO.) | 568-72-9 |
| 分子式 (Formula) | C19H18O3 |
| 分子量 (Molecular Weight) | 294.34 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Xie J, Liu J, Liu H, Liang S, Lin M, Gu Y, Liu T, Wang D, Ge H, Mo SL. The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line. Acta Pharm Sin B. 2015 Nov;5(6):554-63. doi: 10.1016/j.apsb.2015.07.008. Epub 2015 Sep 26. PMID: 26713270; PMCID: PMC4675810.[2]Zhang Z, Li Y, Sheng C, Yang C, Chen L, Sun J. Tanshinone IIA inhibits apoptosis in the myocardium by inducing microRNA-152-3p expression and thereby downregulating PTEN. Am J Transl Res. 2016 Jul 15;8(7):3124-32. PMID: 27508033; PMCID: PMC4969449.[3]Su CC, Chiu TL. Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. Oncol Rep. 2016 Aug;36(2):1173-9. doi: 10.3892/or.2016.4857. Epub 2016 Jun 7. PMID: 27277844.
