N-Ethylmaleimide (NEM)
产品介绍
N-Ethylmaleimide是一种马来酸衍生物，可烷基化游离巯基，作为不可逆的半胱氨酸蛋白酶抑制剂；该化合物特异性抑制线粒体磷酸盐转运，并能通过使内源性去泛素化酶失活，用于蛋白质与多肽中半胱氨酸残基的修饰。
产品性质
产品特色
| 英文别名 (English Synonym) | N-Ethylmaleimide (NEM) |
| 中文名称 (Chinese Name) | N-乙基马来酰亚胺 |
| CAS号 (CAS NO.) | 128-53-0 |
| 分子式 (Formula) | C6H7NO2 |
| 分子量 (Molecular Weight) | 125.13 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
存储条件
-25~-15℃保存，有效期3年
COA
已发表文献
[1] Yellaturu CR, Bhanoori M, Neeli I, Rao GN. N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A. J Biol Chem. 2002 Oct 18;277(42):40148-55. doi: 10.1074/jbc.M206376200. Epub 2002 Aug 8. PMID: 12171932.
[2] Matsuda H, Li Y, Yoshikawa M. Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats. Life Sci. 1999;65(2):PL27-32. doi: 10.1016/s0024-3205(99)00241-6. PMID: 10416830.
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