Nuciferine是一种天然阿朴啡类生物碱，作为5-HT2A/2B/2C受体拮抗剂及5-HT7反向激动剂，具有调节血脂、降压、抗心律失常和促进胰岛素分泌等多重药理活性。
| 英文别名 (English Synonym) | Nuciferine |
| 中文名称 (Chinese Name) | 荷叶碱 |
| 靶点 (Target) | Others |
| 通路 (Pathway) | Natural Products |
| CAS号 (CAS NO.) | 475-83-2 |
| 分子式 (Formula) | C19H21NO2 |
| 分子量 (Molecular Weight) | 295.38 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL. In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. PLoS One. 2016 Mar 10;11(3):e0150602. doi: 10.1371/journal.pone.0150602. PMID: 26963248; PMCID: PMC4786259.[2]Chan JD, Acharya S, Day TA, Marchant JS. Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist. Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):364-370. doi: 10.1016/j.ijpddr.2016.06.001. Epub 2016 Jun 23. PMID: 27397763; PMCID: PMC5196489.
