阿米卡星（BAY 41-6551）是一种半合成卡那霉素衍生物，对多数革兰氏阴性菌（包括庆大霉素和妥布霉素耐药株）具有强效抗菌活性。尽管存在耳毒性与肾毒性风险，其在抗菌、抗癌及镇痛机制研究中仍具重要价值。
|
英文别名 (English Synonym) |
Amikacin |
|
中文名称 (Chinese Name) |
丁胺卡那霉素；阿米卡星 |
|
靶点 (Target) |
Antibiotic |
|
通路 (Pathway) |
Microbiology/Virology |
|
CAS号 (CAS NO.) |
37517-28-5 |
|
分子式 (Formula) |
C22H43N5O13 |
|
分子量 (Molecular Weight) |
585.6 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于H2O |
-25~-15℃保存，有效期3年
[1] Farhan SM, El-Baky RMA, Abdalla S, El-Gendy AO, Ahmed HR, Mohamed DS, El Zawily A, Azmy AF. In Vitro and In Vivo Effect of Amikacin and Imipenem Combinations against Multidrug-Resistant E. coli. Trop Med Infect Dis. 2022 Oct 2;7(10):281. doi: 10.3390/tropicalmed7100281. PMID: 36288022; PMCID: PMC9609961.[2]Atamer-Simsek S, Olmez-Salvarli H, Güc O, Eroglu L. Antinociceptive effect of amikacin and its interaction with morphine and naloxone. Pharmacol Res. 2000 Mar;41(3):355-60. doi: 10.1006/phrs.1999.0599. PMID: 10675289.
