Epidermal growth factor (EGF) is a small, potent growth factor capable of inducing cell proliferation, differentiation, and survival. EGF is the founding member of the EGF family that also includes TGF-alpha, amphiregulin (AR), betacellulin (BTC), epiregulin (EPR), heparin binding EGFlike growth factor (HB?EGF), epigen, and the neuregulins (NRG)-1 through -6. Members of The EGF family are characterized by a shared structural motif, the EGF?like domain, which contains three intramolecular disulfide bonds that are formed by six similarly spaced, conserved cysteine residues. These disulfide bonds are essential for proper protein conformation and receptor binding. All EGF family members are synthesized as type I transmembrane precursor proteins that may contain several EGF domains in the extracellular region. The mature proteins are released from the cell surface by regulated proteolysis. The full length EGF protein is 1207 amino acids (aa) (EGF precursor) containing nine EGF domains and nine LDLR class B repeats. However, the mature protein is much smaller, only 53 aa, and is generated by proteolytic cleavage of the EGF domain proximal to the transmembrane region. EGF is well conserved across mammals with mature human EGF 70% identical to mature mouse and rat EGF. Physiologically, EGF is found in various body fluids, including blood, milk, urine, saliva, seminal fluid, pancreatic juice, cerebrospinal fluid, and amniotic fluid. EGF is a high affinity ligand of the EGF receptor (ErbB). Four ErbB (HER) family receptor tyrosine kinases including EGFR/ErbB1, ErbB2, ErbB3 and ErbB4, mediate responses to EGF family members. EGF binding induces dimerization of the EGF receptor resulting in activation of the protein tyrosine kinase signaling pathway. These receptors undergo a complex pattern of ligand-induced homo- or hetero-dimerization to transduce EGF family signals. EGF binds ErbB1 and depending on the context, induces the formation of homodimers or heterodimers containing ErbB2.
高纯度、高活性、低内毒素、高批间一致性
类器官培养
小鼠气管类器官呈球形或椭球形的闭合囊泡结构，表面光滑均匀，无明显破碎或松散聚集。
小鼠肾类器官呈球形或椭球形，表面光滑，无明显破损或中心坏死。
小鼠胃类器官具有明显的立体感，边界（即最外层的上皮细胞）非常清晰、光滑、明亮，形成一个封闭的腔状结构。
小鼠小肠类器官三维立体，非扁平或弥散状，囊腔完整，无破裂、无实性结节，在初始的囊状结构上，长出多个亮晶晶的、触手状的突起。
-25 ~ -15℃保存，收到货之后有效期1年。
复溶后，无菌条件下，2~8℃保存，7天有效期。复溶后， 无菌条件下，-85 ~ -65℃保存，3个月有效期。
