This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene.

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Flow cytometric analysis of Peroxiredoxin 1 expression in HepG2 cells using Peroxiredoxin 1 antibody . Green, isotype control; red, Peroxiredoxin 1.

Immunocytochemical staining of HepG2 cells with Peroxiredoxin 1 antibody . Nuclei were stained blue with DAPI; Peroxiredoxin 1 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar, 20 μm.

Western blotting analysis using Peroxiredoxin 1 antibody . Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Peroxiredoxin 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively. Image was developed using FeQ™ ECL Substrate Kit .

Western blotting analysis using Peroxiredoxin 1 antibody . Peroxiredoxin 1 expression in wild type (WT) and peroxiredoxin 1 shRNA knockdown (KD) Hela cells with 30 μg of total cell lysates. β-Tubulin serves as a loading control. The blot was incubated with Peroxiredoxin 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively. Image was developed using FeQ™ ECL Substrate Kit .

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