This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
推荐稀释比 WB:1/500-1/1000; IHC:1/50-1/100

Western blot analysis of TNF alpha in Recombinant Human TNF a Protein using TNF α antibody.

Immunohistochemistry analysis of paraffin-embedded Human Tonsil Tissue using TNF aantibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
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