GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). It is a constitutively expressed resident protein of the ER in all eukaryotic cells. Recently it has been reported that GRP78 is associated with apoptosis or inhibition of cancer cell growth. 11587-1-AP antibody recognizes one or two bands with MW 70-78 kDa for the signal peptide of GRP78 protein can be finally cleaved.

推荐稀释比 WB:1/1000-1/5000; IHC:P:1/200-1/500

Western blot analysis of GRP78 BiP in C6 lysates using GRP78 BiP antibody.

Immunohistochemistry analysis of paraffin-embedded Human breast cancer using GRP78 BiP antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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