Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity).

推荐稀释比 WB:1/1000

Western blot analysis of SH3BP4A in ZF4 lysates using SH3BP4A antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。