Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure.Specifically recognizes and binds proteins with a RFXV motif .

Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity.

推荐稀释比 WB:1/500-1/3000;IHC:1/50-1/100

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。