Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;ICC-1/100-1/200

Western blot analysis of Phospho-SHC (Tyr427) in 293 lysates using Phospho-SHC (Tyr427) antibody.

Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue using Shc1(Phospho-Tyr427) antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Sample with blocking peptide on the right.

Immunofluorescence analysis of Phospho-SHC (Tyr427) in Hela cells using Shc1(Phospho-Tyr427) antibody(red).

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。