This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;ICC-1/100-1/200

Western blot analysis of Phospho-c-Cbl (Tyr700) in HT-29 lysates using Phospho-c-Cbl (Tyr700) antibody.

Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue using c-Cbl(Phospho-Tyr700) antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Sample with blocking peptide on the right.

Immunofluorescence analysis of Phospho-c-Cbl (Tyr700) in Hela cells using c-Cbl(Phospho-Tyr700) antibody(red).

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。