EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLC gamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (LNCR).

推荐稀释比 ELISA:1/1000-1/5000;WB:1/1000-1/5000;IHC-P:1/50-1/100

Western blot analysis of recombinant EGFR(L858R) and wild type proteins. Purified His-tagged EGFR(L858R) protein (amino acid 702-987, lane 2) and corresponding wild type protein (amino acid 702-987, lane 1) were blotted with anti EGFR(L858R) mouse monoclonal antibody. Proteins loading (bottom) were blotted with anti-His-tag monoclonal antibody.

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