The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Immunohistochemistry analysis of paraffin-embedded Human colon tissue using TDG antibody.High-pressure and temperature Tris-EDTA pH 8.5 was used for antigen retrieval.

Store at 4°C short term. Aliquot and store at -36°C long term. Avoid freeze/thaw cycles.