After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex.Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4.In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways .

Use at an assay dependent concentration.

Store at 4°C for at least 12 months. Avoid freeze/thaw cycles