This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues .

推荐稀释比 WB:1/500-1/1000;IHC:1/100-1/200;FC:1/50-1/100;ELISA:1/10000

Western blot analysis of MEK4 in HepG2 (1), K562 (2), and HEK293 (3) cell lysate using MEK4 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。