Raf kinase inhibitor protein (RKIP) is a member of the phosphatidylethanolamine-binding protein (PEBP) family that associates with Raf-1 and the MEK and MAP kinases. RKIP has been shown to complex with Raf-1, MEK, and ERK. Although MEK and ERK can simultaneously bind RKIP, the association between Raf-1 and RKIP and that of RKIP and MEK are mutually exclusive. Thus, RKIP competitively disrupts the Raf-1-MEK complex and effectively terminates signal transmission from Raf-1 to MAP kinases.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;IP:1/20

Western blot analysis of RKIP in rat Brain, C6, 3T3, Hela lysates using RKIP antibody.

Immunohistochemistry analysis of paraffin-embedded Human tonsil using RKIP antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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