The MPO gene encodes myeloperoxidase, a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear (PMN) leukocytes and monocytes. In response to stimulation, MPO is activated into a transient intermediate with potent antimicrobial oxidizing abilities. The mRNA is translated into a single protein of 90 kDa, which displays enzymatic activity and undergoes proteolytic maturation into a heavy chain of 59 kDa and a light chain of 13. 5 kDa; these subunits then dimerize into the mature tetramer and the mature MPO is a heterotetramer composed of two identical heavy chains and two identical light chains. Fragments with molecular masses of 43-47 kDa were formed by autocatalysis during warming in sample buffer. The 24-kDa material had a map identical to that of 13. 5 kDa subunit and represents a dimer of the 13. 5 kDa subunit. Defects in MPO are the cause of myeloperoxidase deficiency (MPOD).

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;IF:1/50-1/200

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。