The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

推荐稀释比 WB:1/500-1/1000;IF:1:50/1:200

Immunocytochemistry analysis of SAE1 (green) in Hela using SAE1 antibody,and DAPI(blue).

Western blot analysis of SAE1 in Hela, Jurkat lysates using SAE1 antibody.

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