The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of Cathepsin L in mouse kidney, A172 lysates using Cathepsin L antibody

Immunohistochemistry analysis of paraffin-embedded Human thyroid cancer using Cathepsin L antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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