Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of PPP2R4 in PC-3 and MCF-7 lysates using PPP2R4 antibody.

Immunohistochemistry analysis of paraffin-embedded Human thyroid cancer using PPP2R4 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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